135531-86-1 | Camalexin

Chemical type

• Indole-type phytoalexin (indolic phytoalexins/alkaloids)

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• Indole phytoalexin (Plant-derived secondary metabolite)

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Key properties

• Synthesized from tryptophan via indole-3-acetaldoxime (IAOx)
• Broad antimicrobial activity against fungi and bacteria
• Induced by pathogen-triggered immunity (PTI/ETI)
• Regulated by WRKY TFs and SA/JA signaling

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• Antiproliferative and cancer chemopreventive effects
• Induces oxidative stress (Reactive Oxygen Species - ROS) in cancer cells
• Promotes lysosomal membrane permeabilization (LMP) and cathepsin D (CD) release
• Selectively more cytotoxic towards aggressive/metastatic prostate cancer cell lines (e.g., C4-2, ARCaPM) compared to less aggressive ones (e.g., LNCaP, ARCaPE)

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• Antimicrobial defense in Arabidopsis and crucifers
• Inhibits pathogen growth and contributes to innate immunity

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• Potential novel therapeutic agent for the treatment of metastatic prostate cancer
• Research tool for studying ROS-induced and lysosome-mediated apoptosis pathways

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Classification by use

• Phytoalexins used in fungal and bacterial resistance
• Inducible secondary metabolites for biotic stress response

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• Chemicals with potential therapeutic use in cancer treatment
• Chemicals used in biological/mechanistic research (apoptosis, oxidative stress)

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [1] Redefining phytoalexins as engineered defenses for plant disease resistance, Current Plant Biology, Volume 45, January 2026, 100577
2. [2] Camalexin-Induced Apoptosis in Prostate Cancer Cells Involves Alterations of Expression and Activity of Lysosomal Protease Cathepsin D, Molecules, 2014, 19(4), 3988-4005