What is the Methyl isonipecotate?

Methyl isonipecotate is White to off-white crysrallic powder, while it's Molecular Formula is C7H13NO2. White to off-white crysrallic powder 4-Piperidinecarboxylic acid methyl ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.

What is the CAS number for Methyl isonipecotate?

The CAS number of Methyl isonipecotate is 2971-79-1.

What is Methyl isonipecotate (2971-79-1) used for?

Methyl isonipecotate, also known as 4-piperidinecarboxylic acid methyl ester, is a colorless liquid that can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C. It is an ester derivative of 4-piperidinecarboxylic acid and serves as a versatile reactant in the synthesis of various biologically active compounds.InChI:InChI=1/C7H13NO2/c1-10-7(9)6-2-4-8-5-3-6/h6,8H,2-5H2,1H3

What is the Methyl isonipecotate?

Methyl isonipecotate is White to off-white crysrallic powder, while it's Molecular Formula is C7H13NO2. White to off-white crysrallic powder 4-Piperidinecarboxylic acid methyl ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.

What is the CAS number for Methyl isonipecotate?

The CAS number of Methyl isonipecotate is 2971-79-1.

What is Methyl isonipecotate (2971-79-1) used for?

Methyl isonipecotate, also known as 4-piperidinecarboxylic acid methyl ester, is a colorless liquid that can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C. It is an ester derivative of 4-piperidinecarboxylic acid and serves as a versatile reactant in the synthesis of various biologically active compounds.InChI:InChI=1/C7H13NO2/c1-10-7(9)6-2-4-8-5-3-6/h6,8H,2-5H2,1H3

methyl 4-piperidinecarboxylate

Basic information

Product Name:methyl 4-piperidinecarboxylate
CasNo.:2971-79-1
MF:C₇H₁₃NO₂

Physical and Chemical Properties

Purity:99%
Melting Point:50oC
Appearance:White to off-white crysrallic powder

Inquiry

Product Details

CasNo： 2971-79-1

MF： C₇H₁₃NO₂

Appearance： White to off-white crysrallic powder

Factory Export Top Purity methyl 4-piperidinecarboxylate 2971-79-1 In Stock

Molecular Formula:C7H13NO2
Molecular Weight:143.186
Appearance/Colour:White to off-white crysrallic powder
Vapor Pressure:0.457mmHg at 25°C
Melting Point:50oC
Refractive Index:1.465
Boiling Point:193.8 °C at 760 mmHg
PKA:9.78±0.10(Predicted)
Flash Point:71 °C
PSA：42.91000
Density:1.021 g/cm³
LogP:0.70200

methyl 4-piperidinecarboxylate(Cas 2971-79-1) Usage

Methyl 4-piperidinecarboxylate is a colorless to pale yellow liquid that serves as an important intermediate in organic synthesis. As a derivative of piperidine characterized by a carboxylic acid ester group attached to the fourth carbon of the piperidine ring, it typically appears as a clear liquid. This compound is synthesized through specific chemical reactions, such as the esterification of 4-piperidinecarboxylic acid with methanol under suitable conditions. Methyl 4-piperidinecarboxylate finds applications in drug development, pesticide synthesis, and materials science. In drug synthesis, it may act as a key structural unit for molecules with specific pharmacological activity, particularly those targeting the central nervous system. Additionally, it plays a role in the production of agrochemicals and other specialized chemicals, making it a versatile component in various industries.

InChI:InChI=1/C7H13NO2/c1-10-7(9)6-2-4-8-5-3-6/h6,8H,2-5H2,1H3

2971-79-1 Relevant articles

Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers

Harris,Nation,Copeland,Miller

, Bioorganic & Medicinal Chemistry Letters Volume 21, Issue 19 , 1 October 2011, Pages 5910-5915

To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 4-piperidinecarboxylate and 4-piperidinecyanide derivatives were prepared and evaluated for in vitro and in vivo activity against α1G calcium channel. Among them, several compounds showed good T-type calcium channel inhibitory activity and minimal off-target activity over hERG channel (% inhibition at 10 μM = 61.85–71.99, hERG channel IC50 = 1.57 ± 0.14–4.98 ± 0.36 μM). Selected compound 31a was evaluated on SNL model of neuropathic pain and showed inhibitory effect on mechanical allodynia.

The face selectivity of 1,3-dipolar cycloaddition reactions of 4-butyloxycarbonyl-3,4,5,6-tetrahydropyridine 1-oxide

Alsbaiee, Alaaeddin,Ali, Shaikh A.

, p. 6635 - 6644 (2008)

A study of the stereo- and face selectiv...

Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors

Liao, Chenzhong,Tian, Yongbin,Xie, Zhouling

supporting information, (2020/02/27)

Currently, synergistic inhibition of pol...

2971-79-1 Process route

: 1262670-73-4
N-tritylisonipecotic acid methyl ester

: 2971-79-1
isonipecotic acid methyl ester

Conditions

Conditions	Yield
With ammonium cerium (IV) nitrate; water; acetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;	89%

: 67-56-1
methanol

: 498-94-2
isonipecotic acid

: 2971-79-1
isonipecotic acid methyl ester

Conditions

Conditions	Yield
With thionyl chloride; at 0 ℃; Reflux;	99%
With hydrogenchloride; for 4h;	70%
With thionyl chloride;
With thionyl chloride; for 1h; Heating;
With hydrogenchloride; for 3h; Heating;
With thionyl chloride; at 20 ℃;
With thionyl chloride; at 0 - 20 ℃; for 18h;
With thionyl chloride; at 0 - 20 ℃; for 18h;
With thionyl chloride; at 0 - 20 ℃; for 18h;
With sulfuryl dichloride; at 20 - 50 ℃;
With thionyl chloride; at 0 - 20 ℃; for 18h;
With thionyl chloride; In methanol; at 0 - 25 ℃; for 12h;
With thionyl chloride; at 0 ℃; for 1h; Inert atmosphere; Reflux;