26675-46-7 | Isoflurane

Chemical type

• Inhaled anesthetic (halogenated ether)

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• Halogenated ether compound
• Volatile anesthetic

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• Halogenated inhalation anesthetic

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Key properties

• Volatile liquid providing rapid induction and recovery
• Used at 4% for induction and 2% for maintenance
• Ensures controlled anesthesia during surgical procedures

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• Biphasically modulates TTX-R Na⁺ channels (Naᵥ1.8) (potentiation at low conc., inhibition at high conc.)
• Shifts the voltage-inactivation relationship to a hyperpolarizing range
• Accelerates the development of inactivation and retards the recovery from inactivation of TTX-R Na⁺ channels
• Inhibits persistent sodium currents (I_NaP)
• Inhibits leak potassium conductance (K2P channels)
• Depolarizes nociceptive neurons
• Effects are dampened under acidic pH (e.g., pH 6.5) conditions

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• Used for general anesthesia in humans and animals
• Neurotoxic effects observed at low doses in animals (apoptosis, caspase 3 activation)
• Reproductive toxicity in male rats (histopathological changes in testes, decreased serum FSH and testosterone)
• Relatively low occupational exposure limits (OELs) derived due to sensitivity of male fertility

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• Anesthesia for ICH model establishment in rats
• Maintenance during stereotaxic injections

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• Induction of general anesthesia (unconsciousness, amnesia, immobility, analgesia)

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• General anesthesia in hospital and veterinary settings
• Research use in animal facilities

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Classification by use

• Inhaled anesthetics for animal surgery
• Agents for procedural sedation in research

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• Pharmaceuticals (Anesthetic)
• Central Nervous System Agents

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] 17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats, International Immunopharmacology, Volume 123, October 2023, 110698
2. [Cite:2] Effects of isoflurane on tetrodotoxin-resistant Na⁺ channels in rat nociceptive sensory neurons: Roles of concentration and extracellular Ph, Biomedicine & Pharmacotherapy, Volume 193, December 2025, 118746
3. [Cite:3] A health-based recommended occupational exposure limit for isoflurane and sevoflurane using experimental animal data based on a systematic review and dose-response analysis, Environmental Toxicology and Pharmacology, Volume 121, January 2026, 104916