298-46-4 | Carbamazepine

Chemical type

• Antiseizure medication (ASM) and potential P-gp substrate

^[1]

• Antiepileptic drug
• Pharmaceutical

^[2]

Key properties

• Enzyme-inducing ASM that may lower tariquidar plasma levels at low doses
• Brain entry potentially limited by P-gp overactivity

^[1]

• Long-established anticonvulsant and mood stabilizer
• Metabolized into an active metabolite (carbamazepine-10,11-epoxide)
• Can cause neurological adverse effects (drowsiness, dizziness, ataxia, dysarthria) even at therapeutic levels, especially in drug-naive individuals
• Half-life of 12-17 hours for the parent compound

^[2]

• Treatment of drug-resistant epilepsy (e.g., mesial temporal lobe epilepsy)
• Co-administered with P-gp inhibitors in studies

^[1]

• Treatment of epilepsy
• Management of bipolar disorder
• Relief of trigeminal neuralgia

^[2]

Classification by use

• Chemicals used as antiseizure medications
• Enzyme inducers in pharmacotherapy

^[1]

• Essential medicine

^[2]

A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Tolerability of tariquidar – A third generation P-gp inhibitor as add-on medication to antiseizure medications in drug-resistant epilepsy, Seizure: European Journal of Epilepsy, Volume 119, July 2024, Pages 44-51
2. [Cite:2] Criminal use of carbamazepine: A case of drug-facilitated captivity in Lubumbashi, DR Congo, Forensic Science International: Reports, Volume 13, June 2026, 100441