Furosemide

CAS: 54-31-9

Category: Sulfonamide

PurityPharmaceutical Grade (EP, USP, BP) 98.0–102.0% (on dried basis), Reagent Grade ≥98%, Reference Stand
Molecular FormulaC₁₂H₁₁ClN₂O₅S
Molecular Weight330.74
AppearanceWhite to slightly yellow crystalline powder
Packaging25kg/fiber drum or plastic-lined paper bag; 1kg/5kg/aluminum foil bag; 100g/500g/plastic bottle (for pharmaceutical intermediate use)
Testing IndicatorsAppearance — Visual inspection; Identification — IR, UV, or HPLC; Assay — HPLC or titration (potentiometric); Related substances (impurities) — HPLC; Loss on drying — Gravimetry; Sulfated ash — Muffle furnace; Heavy metals — ICP-MS or colorimetry; Residual solvents — GC; Chloride content — Ion chromatography; Particle size — Laser diffraction (for formulation); Microbial limits — Plate count method.
Storage NotesStored in a tightly sealed container in a cool, dry, well-ventilated area, protected from light and moisture, away from strong acids, strong bases, strong oxidizers, and incompatible materials; store at controlled room temperature (15–30°C).
Lead Time
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days
Used as a potent loop diuretic in the treatment of edema associated with congestive heart failure, liver cirrhosis, renal disease (including nephrotic syndrome), and hypertension; also used in veterinary medicine; acts by inhibiting the Na⁺-K⁺-2Cl⁻ symporter (NKCC2) in the thick ascending limb of the loop of Henle.