2-amino-N-(2-methylphenyl)benzamide
CAS: 4943-85-5
Category: Benzamide
| Purity | Research Grade ≥95%, High-Purity Grade ≥98%, Pharmaceutical Intermediate Grade ≥99%, Analytical Refe |
| Molecular Formula | C₁₄H₁₄N₂O |
| Molecular Weight | 226.27 |
| Appearance | White to off-white to pale yellow crystalline powder |
| Packaging | 1g/5g/10g/25g/100g/500g/plastic bottle or aluminum foil bag; 1kg/5kg/25kg/fiber drum or plastic drum; custom packaging for bulk orders |
| Testing Indicators | Appearance — Visual inspection; Identification — NMR (¹H, ¹³C), FTIR (characteristic amide C=O stretch ~1640–1680 cm⁻¹, N-H stretches), or LC-MS; Purity — HPLC (C18 column, UV detection at 220–280 nm); Melting point — Capillary method; Water content — Karl Fischer titration or loss on drying; Residual solvents — GC; Heavy metals — ICP-MS; Related impurities (unreacted starting materials, isomeric byproducts) — HPLC; Assay — Titration (non-aqueous acid-base for amine content) or HPLC; Mass verification — Mass spectrometry (ESI or EI). |
| Storage Notes | Stored in a tightly sealed container in a cool, dry, well-ventilated area, protected from light and moisture; away from strong oxidizers, strong acids, strong bases, and heat sources; stable at room temperature; keep container closed when not in use to prevent absorption of CO₂ (the primary amine may react with CO₂ to form carbamate). |
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Used as a synthetic intermediate in the preparation of pharmaceuticals, agrochemicals, and heterocyclic compounds; as a building block for the synthesis of quinazolinones, benzodiazepines, and other fused heterocycles with potential biological activities (anticonvulsant, anti-inflammatory, anticancer, antimicrobial); the ortho-amino group allows for cyclization reactions with carbonyl compounds, aldehydes, and isocyanates; the o-tolyl group provides steric and electronic modulation; used in medicinal chemistry for structure-activity relationship (SAR) studies of benzamide-based drug candidates (e.g., histone deacetylase (HDAC) inhibitors, dopamine receptor ligands).