Neodiospyrin
CAS: 33916-25-5
Category: Naphthoquinone dimer (Dimeric naphthoquinone, natural product, binaphthoquinonoid)
| Purity | Research Grade ≥90% (isolated from natural source), High-Purity Grade ≥95% (HPLC), Analytical Refere |
| Molecular Formula | C22H14O6 |
| Molecular Weight | 374.3 |
| Appearance | Red, orange-red, purple-red, or dark brown crystalline solid (characteristic of naphthoquinone pigments) |
| Packaging | 1mg/5mg/10mg/25mg/50mg/100mg/glass vial (for research) |
| Testing Indicators | Appearance — Visual inspection (characteristic red/orange/red-purple color); Identification — NMR (¹H, ¹³C, 2D-COSY, HMBC), FTIR (characteristic quinone C=O stretches ~1640–1680 cm⁻¹, aromatic C=C ~1450–1600 cm⁻¹), UV-Vis spectroscopy (characteristic naphthoquinone absorption bands ~250–280 nm, ~330–350 nm, ~420–480 nm), or LC-MS/MS; Purity — HPLC (C18 column, UV detection at 254–400 nm, diode array detection recommended for peak purity); Mass verification — High-resolution mass spectrometry (HRMS-ESI or MALDI); Melting point — Capillary method; Optical rotation — Polarimetry (if chiral); Water content — Karl Fischer titration; Residual solvents — GC; Heavy metals — ICP-MS; Related substances (monomeric naphthoquinones, other dimeric isomers, degradation products) — HPLC-MS; Antioxidant activity — DPPH or ABTS assay (for functional characterization). |
| Storage Notes | Stored in a tightly sealed, light-protected container (amber glass vial) under inert atmosphere (nitrogen or argon) at -20°C (long-term) or 2–8°C (short-term); protected from light, oxygen, moisture, and heat; away from strong oxidizers, strong acids, strong bases, and reducing agents; handle with standard laboratory precautions for cytotoxic natural products. |
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Used as a research chemical in natural products chemistry, cancer pharmacology, and antimicrobial studies; a dimeric naphthoquinone isolated from certain Diospyros species (Ebenaceae family, e.g., persimmon, ebony trees); exhibits a broad range of biological activities including antitumor (cytotoxic against various cancer cell lines), antibacterial, antifungal, antimalarial, anti-inflammatory, and antioxidant properties; acts as a topoisomerase inhibitor and induces apoptosis in cancer cells; studied for structure-activity relationship (SAR) of binaphthoquinonoids and their potential as lead compounds for drug development; also investigated for its ability to generate reactive oxygen species (ROS) and interfere with cellular redox balance.