Flurbiprofen
CAS: 5104-49-4
Category: NSAIDs
| Purity | Reagent Grade ≥98%, Standard Grade ≥98.5%, High-Purity Grade ≥99%, Pharmaceutical Grade ≥99.0–100.5% |
| Molecular Formula | C15H13FO2 |
| Molecular Weight | 244.26 |
| Appearance | White to off-white crystalline powder |
| Packaging | 100 mg/glass vial, 250 mg/glass vial, 500 mg/glass vial, 1 g/glass vial, 5 g/glass vial, 25 g/HDPE bottle, 100 g/HDPE bottle, or 1 kg/aluminum foil bag |
| Testing Indicators | Appearance — Visual inspection (white to off-white crystalline powder); Melting point — Capillary method (110–112°C, literature; 113.0–118.0°C, TCI specification; 114.0–117.0°C, Ruifu Chemical); Boiling point — Distillation (376.2±30.0°C at 760 mmHg, predicted); Density — Hydrometer (1.1795 estimate, ChemicalBook; 1.199±0.06 g/cm³, Ruifu Chemical); Purity — HPLC-UV (≥98–99.5%, C18 column, acetonitrile:buffer gradient, λ=220–254 nm, RT ~3.2 min); Related substances — HPLC (impurity profiling including 2-fluorobiphenyl, 3-fluoro-4-phenylhydratropic acid, and other synthesis-related impurities); Assay — RP-HPLC (linearity 5–50 µg/mL, R²>0.9996, recovery 97.07–103.66%) or neutralization titration (TCI: min. 98.0%; Ruifu Chemical: 99.0–100.5%); Loss on drying — Gravimetric (≤0.5%); Residue on ignition — Gravimetric (≤0.1%); Heavy metals — Colorimetric/ICP-MS (≤10–20 ppm); Identification — FTIR (characteristic peaks: O–H (carboxylic acid) ~2500–3300 cm⁻¹ broad, aromatic C–H ~3000–3100 cm⁻¹, aliphatic C–H ~2850–2950 cm⁻¹, C=O (carboxylic acid) ~1700–1720 cm⁻¹, aromatic C=C ~1600 cm⁻¹, C–F ~1100–1300 cm⁻¹, C–O ~1200–1250 cm⁻¹); UV spectrophotometry (PDA detector, λmax ~220–254 nm); ¹H NMR (DMSO-d₆ or CDCl₃: δ 1.50 ppm doublet CH₃, δ 3.80 ppm quartet CH, δ 7.20–7.80 ppm multiplet aromatic protons, δ 12.50 ppm broad singlet COOH); ¹³C NMR (DMSO-d₆: δ 18 ppm CH₃, δ 45 ppm CH, δ 115–150 ppm aromatic carbons, δ 175 ppm carboxylic acid C=O); Mass spectrometry — EI-MS (m/z 244 [M]⁺, source temperature 130°C, sample temperature 110°C, 75 eV); Water content — Karl Fischer titration (GB/T 6283/EP 2.5.12); pH — Potentiometry (saturated aqueous solution, weakly acidic, pKa ~3.80); Specific optical rotation — Not applicable (racemic mixture, RS configuration); Solubility — DMSO (≥100 mg/mL), methanol (≥50 mg/mL, almost transparent), ethanol, slightly soluble in water (8 mg/L). |
| Storage Notes | Store in a cool, dry, well-ventilated area at room temperature (15–30°C) or 2–8°C. Protect from light, moisture, and air. Keep container tightly sealed. Store powder at -20°C for long-term stability (up to 3 years); at 4°C for 2 years. In solvent, store at -80°C for 2 years or at -20°C for 1 year. Light-sensitive material; avoid prolonged exposure to light and humid conditions. TCI recommends storage in a cool and dark place below 15°C. Store away from strong oxidizing agents and incompatible substances. |
| Lead Time | 10 days |
Flurbiprofen (INN, also known as Ansaid, Froben, Flurizan, or L-790,330) is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid derivative class. It functions as a potent, non-selective cyclooxygenase (COX) inhibitor with IC50 values of 0.1 µM and 0.4 µM for human COX-1 and COX-2, respectively. It exhibits anti-inflammatory, analgesic, antipyretic, neuroprotective, anti-metastatic, and anticancer chemotherapeutic activities. In vivo, flurbiprofen suppresses cerebral ischemia/reperfusion injury by decreasing infarct volume, apoptosis, and neurological deficits. In cellular and animal models of gastric cancer, it downregulates cyclin D1 and CDK4 expression, upregulates p75 expression, and decreases cellular proliferation, metastasis, and tumor size. Used as a pharmaceutical intermediate and active pharmaceutical ingredient (API) for the development and quality control of oral tablets, topical patches, ophthalmic solutions, and transdermal delivery systems. Approved for clinical use in the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and mild to moderate pain. Also employed in analytical method development, pharmacokinetic studies, forced degradation studies, and quality control applications. ATC code: M01AE09.