2-(Dicyclohexylphosphino)-2'-methylbiphenyl
CAS: 251320-86-2
Category: Organic Pharmaceutical Intermediates
| Purity | Catalyst Grade ≥98%; Research Grade ≥99%; HPLC Grade ≥99% |
| Molecular Formula | C25H33P |
| Molecular Weight | 364.50 |
| Appearance | White to off-white crystalline powder |
| Packaging | 1 g, 5 g, 10 g, 25 g, 100 g fluorinated bottle or amber glass bottle; custom bulk packaging available |
| Testing Indicators | Appearance — Visual inspection; Identification — ¹H NMR, ¹³C NMR and ³¹P NMR; Molecular weight — HRMS or LC-MS; Purity — HPLC (UV) and/or GC; Phosphine oxide impurity — ³¹P NMR or HPLC; Water content — Karl Fischer titration (GB/T 6283); Residual solvents — GC (ICH Q3C); Melting point — Capillary melting point determination; Elemental analysis — CHN analysis where applicable. |
| Storage Notes | Store tightly sealed in a cool, dry, well-ventilated place under an inert atmosphere (nitrogen or argon). Protect from moisture, oxygen, direct sunlight, and sources of ignition. Recommended storage temperature: 2–8°C for long-term stability. Handle under inert gas whenever possible. |
| Lead Time | 10 days |
A bulky electron-rich biaryl monophosphine ligand widely used in transition-metal catalysis, especially palladium-catalyzed Suzuki-Miyaura, Buchwald-Hartwig amination, Negishi, Stille, and other C-C/C-N cross-coupling reactions. Frequently employed as a ligand for the preparation of highly active palladium catalyst systems in pharmaceutical, agrochemical, and fine chemical synthesis.