4-(tert-Butyl)-2-chloropyridine
CAS: 81167-60-4
Category: Organic Pharmaceutical Intermediates
| Purity | Research Grade ≥97%; High-Purity Grade ≥98%; Pharmaceutical Intermediate Grade ≥99% |
| Molecular Formula | C9H12ClN |
| Molecular Weight | 169.65 |
| Appearance | Colorless to pale yellow liquid |
| Packaging | 1 g, 5 g, 25 g amber glass bottle with PTFE-lined cap; bulk quantities supplied in sealed fluorinated bottles or metal containers under inert atmosphere |
| Testing Indicators | Appearance — Visual inspection; Identification — FTIR spectroscopy and 1H NMR / 13C NMR; Molecular structure confirmation — GC-MS or LC-MS; Purity — GC-FID or HPLC-UV; Water content — Karl Fischer titration; Residual solvents — GC-MS according to ICH Q3C guidelines; Density — ASTM D4052; Refractive index — ASTM D1218; Chlorine content — ICP-OES or elemental analysis. |
| Storage Notes | Store in a cool, dry, and well-ventilated area away from heat, moisture, and direct sunlight. Keep container tightly sealed. Store under inert atmosphere such as nitrogen or argon for long-term stability. Avoid contact with strong oxidizing agents, strong acids, and strong bases. |
| Lead Time | 10 days |
Used as a halogenated pyridine intermediate in organic synthesis. It is mainly applied in the preparation of pharmaceutical intermediates, agrochemical intermediates, and functional heterocyclic compounds. The chlorine substituent enables nucleophilic substitution and cross-coupling reactions for the synthesis of substituted pyridine derivatives.