(3S,4S)-1-((Benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid
CAS: 2350526-26-8
Category: Pharmaceutical Intermediates
| Purity | Reference/impurity grade: >=95% (HPLC), typically 95-98%; bulk grade: >=97%, >=98% (HPLC) |
| Molecular Formula | C15H19NO4 |
| Molecular Weight | 277.32 |
| Appearance | White to off-white crystalline powder |
| Packaging | 100 mg/vial, 250 mg/vial, 500 mg/vial, 1 g/vial (reference standard grade); 5 g/glass bottle, 10 g/glass bottle, 25 g/glass bottle, 100 g/fluorinated bottle (bulk grade) |
| Testing Indicators | Appearance - visual inspection; Identification - 1H NMR, 13C NMR, FTIR (carbamate C=O ~1690-1710 cm-1, carboxylic acid C=O ~1700-1720 cm-1, broad O-H ~2500-3300 cm-1), HRMS/LC-MS (ESI, [M+H]+ m/z 278.14; [M-H]- m/z 276.12); Purity - HPLC-UV (C18 column, 210-220 nm or 254 nm, acidic aqueous/acetonitrile mobile phase); Chiral purity - chiral HPLC (amylose/cellulose-based chiral column) to confirm (3S,4S) configuration and enantiomeric/diastereomeric excess; Water content - Karl Fischer titration; Residual solvents - GC (if applicable); Heavy metals - ICP-MS/ICP-OES (if applicable); Melting point - capillary method. |
| Storage Notes | Store in a cool, dry, well-ventilated place away from light and heat. Keep container tightly sealed and protect from moisture. Recommended storage at 2-8 degrees C (or -20 degrees C for long-term storage of reference standards). Avoid contact with strong oxidizing agents, strong bases, and moisture. |
| Lead Time | 10 days |
Chiral pyrrolidine building block used in organic and pharmaceutical synthesis; the Cbz group on N-1 is selectively removable by hydrogenolysis, and the C-3 carboxylic acid allows amide/ester formation. Commercially supplied mainly as an Upadacitinib (JAK1 inhibitor) process/degradation impurity reference standard for method development, quality control, and impurity profiling.