Pemetrexed (disodium hemipenta hydrate)

CAS: 357166-30-4

Category: Pyrimidine carboxamide

PurityReagent Grade ≥98%, High-Purity Grade ≥99%, Technical Grade ≥95%
Molecular FormulaC20H24N5Na2O8.5
Molecular Weight516.41
AppearanceWhite to off-white crystalline powder, hygroscopic
Packaging1g/5g/10g or 25kg/cardboard drum or 1kg/aluminum foil bag
Testing IndicatorsAppearance — Visual inspection; Identification — IR, Sodium test; Purity — RP-HPLC; Water content —Karl Fischer titration; Sodium — Flame photometry; Heavy metals — ICP-MS; Microbial limits — Membrane filtration; Folate impurities — LC-MS; pH — Potentiometry.
Storage NotesStored in a cool, dry, and well-ventilated place in a tightly closed, light-resistant USP type-I glass vial, away from incompatible materials, heat, direct sunlight, and moisture.
Lead Time
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days
Used as a folate analog metabolic inhibitor targeting thymidylate synthase and other enzymes in the synthesis of chemotherapeutic agents for non-small cell lung cancer and mesothelioma.