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(R)-2-Hydroxypropanoic acid

CAS No.: 10326-41-7

  • Molecular Formula: C₃H₆O₃
  • Molecular Weight: 90.08 g/mol

Chemical type

  • Organic acid
  • Monomeric precursor for Lactate-based copolymer (LAHB)
[1]
  • Chiral organic acid (α-hydroxy acid, D-enantiomer)
[2]

Key properties

  • Converted to D-LA-CoA by PCT enzymes to become a substrate for polymerization.
[1]
  • Exists as a stereoisomer of lactate
  • Product of glycolysis (via methylglyoxal pathway or LdhA in bacteria)
  • Can be converted into D-lactyl-CoA
  • Acts as a metabolic signaling molecule
  • Accumulates under anaerobic conditions
[2]
  • Feedstock for LAHB biosynthesis.
[1]
  • Drives lysine D-lactylation (post-translational modification)
  • Regulates bacterial metabolism and growth
  • Serves as a metabolic intermediate and signaling molecule
[2]

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  1. [Cite:1] Complete sequence randomness of lactate-based copolymers (LAHBs) with varied lactate monomer fractions employing a series of propionyl-CoA transferases, International Journal of Biological Macromolecules, Volume 274, Part 2, August 2024, 133055
  2. [Cite:2] D-lactate Drives Lysine D-lactylation to Regulate Metabolism in Escherichia coli, JBC, 16 March 2026, 111374