111-30-8 | Glutaraldehyde

Chemical type

• Dialdehyde Fixative

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• Chemical crosslinking agent

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• Dialdehyde cross-linking agent

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Key properties

• Stronger cross-linker than formaldehyde; preserves cellular ultrastructure more effectively for electron microscopy.
• Has better penetration and longer-lasting fixation.

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• Forms uniform network; enhances mechanical strength and flexibility; prevents thermal degradation during processing.

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• Reacts with N-terminal amino groups, α-amino groups of amino acids, and sulfhydryl groups of cysteine
• Forms complex high molecular-weight protein species
• Irreversible chemical modifications to proteins
• Causes structural changes, particularly in protein oligomers (e.g., more dramatic changes in B oligomer than A protomer of pertussis toxin)
• Reduces toxicity by modifying functional domains
• Alters antigenic properties and epitopes
• Effects influenced by concentration (0.05% to 1.0% w/v), buffer pH (6.0 to 9.0), incubation time (4 to 24 hours), and temperature (room temperature)

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• Used in combination with formaldehyde (in FAEG fixative) for SEM sample fixation.

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• Added (1% w/w) for in situ chemical crosslinking of Chit/PCL blends during cryogel fabrication.

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• Detoxification of pertussis toxin for acellular pertussis vaccines
• Inactivation of bacterial toxins by cross-linking subunits
• Protein fixation and modification in biochemical assays

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Classification by use

• Electron Microscopy Fixative
• Histological Fixative

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• Crosslinking agents in polymer scaffolds
• Chemicals for structural stabilization in biomaterials

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• Chemicals used in vaccine production

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Floral ontogeny and development of the model plant Nicotiana benthamiana, Current Plant Biology, Volume 45, January 2026, 100578
2. [Cite:2] Bioactive chitosan/polycaprolactone cryogel sponge co-loaded with ciprofloxacin and ginger for controlled drug release and healing of infected wounds, Materials & Design, Volume 259, November 2025, 114913
3. [Cite:3] Glutaraldehyde modifies the catalytic and binding subunits of pertussis toxin, affecting its toxicity and immunogenicity, Vaccine: X, Volume 27, December 2025, 100732