23214-92-8 | Doxorubicin (DOX)

Chemical type

• Anthracycline anticancer drug
• Positively charged chemotherapeutic agent
• Fluorescent small molecule

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• Anthracycline antibiotic
• Anthraquinone derivative

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• Anthracycline chemotherapy drug

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Key properties

• Protonated amine group enables electrostatic binding to carboxylate-containing carriers
• Intercalates DNA, leading to cytotoxicity primarily in cancer cells
• Releases minimally (13.9% in 12 h) at physiological pH without GSH, but rapidly (84% in 12 h) under acidic/reducing conditions
• IC₅₀ of 0.08 µM in MCF-7 cells when loaded in nanogel (1.6-fold more potent than free DOX)

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• Widely used chemotherapeutic agent
• Causes cumulative dose-dependent cardiotoxicity
• Induces mitochondrial dysfunction and oxidative stress

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• DNA intercalator and topoisomerase II inhibitor
• Well-known apoptosis inducer

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• Model drug for evaluating stimuli-responsive delivery systems
• Chemotherapy for breast cancer and other malignancies
• Fluorescent probe for tracking intracellular localization and release

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• First-choice antitumor drug for malignant solid tumors and acute lymphomas

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• Positive control for apoptosis induction in cancer cell studies

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Classification by use

• Anticancer therapeutics in nanocarrier formulations
• Chemicals used in controlled release studies
• Positively charged cargos for electrostatic loading in drug delivery systems

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• Chemotherapeutic agents
• Chemicals inducing experimental cardiotoxicity/disease models

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• Apoptosis-inducing agents

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Nanogels crosslinked with a novel selenocystine-based linker for triple-stimuli-responsive drug delivery, Chemical Engineering Journal Advances, Volume 25, March 2026, 100959
2. [Cite:2] ANKRD1 knockdown attenuates doxorubicin-induced dilated cardiomyopathy by regulating mitochondrial dysfunction and oxidative stress through activation of the AMPK/AKT/mTOR pathway, Electronic Journal of Biotechnology, Volume 79, January 2026, 100696
3. [Cite:3] PHA-665752’s Antigrowth and Proapoptotic Effects on HSC-3 Human Oral Cancer Cells, Int. J. Mol. Sci., 2024, 25(5), 2871