95058-81-4 | Gemcitabine

Chemical type

• Nucleoside analog
• Antimetabolite

^[1]

• Cytidine analog
• Pyrimidine nucleoside derivative

^[2]

Key properties

• Chemotherapeutic agent
• Interferes with DNA synthesis

^[1]

• High affinity for bacterial transporters (KM 2.5–3.0 µM for NupG orthologs; KM 10–13 µM for NupC orthologs)
• 15–100 times higher affinity than human transporter hENT1/SLC29A1
• Metabolized by gamma-proteobacteria (via cytidine deaminase) to less active deaminated form (2',2'-difluoro-2'-deoxyuridine)
• Incorporated into DNA/RNA, inhibiting nucleotide metabolism and causing cytotoxicity
• Competitively inhibited by natural nucleosides like cytidine and uridine

^[2]

• Chemotherapy drug for high-risk liver hepatocellular carcinoma (HCC) patients
• Shown to have greater sensitivity in treating high-risk HCC patients

^[1]

• Anticancer drug for pancreatic ductal adenocarcinoma and other aggressive cancers
• Frontline chemotherapy agent
• Transported and metabolized by tumor-associated bacteria, contributing to chemoresistance

^[2]

Classification by use

• Chemotherapy drugs

^[1]

• Chemotherapy agents
• Substances involved in bacteria-mediated drug resistance

^[2]

A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Anoikis- and m6A-related lncRNA analysis to identify prognostic indicators in liver hepatocellular carcinoma, Electronic Journal of Biotechnology, Volume 79, January 2026, 100701
2. [Cite:2] Elucidation of the Gemcitabine Transporters of Escherichia coli K-12 and Gamma-Proteobacteria Linked to Gemcitabine-Related Chemoresistance, Int. J. Mol. Sci., 2024, 25(13), 7012