633-65-8 | Berberine Hydrochloride

Chemical type

• Natural alkaloid

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• Quaternary ammonium-type isoquinoline alkaloid

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Key properties

• Low solubility and stability in oral administration
• Antimicrobial activity against pathogens like E. coli, S. aureus, and C. albicans
• Anti-inflammatory effects
• Anticancer properties
• Antidiabetic effects
• Forms inclusion complexes with cyclodextrins for enhanced bioavailability

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• One of the important active components in Chinese herbal medicine
• Exhibits high peak absorption at 225-235 nm, 263-268 nm, 344-352 nm, and 427-431 nm

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• Model drug in hydrogel formulations
• Oral delivery for therapeutic effects
• Antimicrobial agent
• Anti-inflammatory treatment
• Anticancer therapy
• Antidiabetic medication

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• Used as a quantitative index component (marker) for quality control and standardization of Corydalis conspersa. It is also a key active ingredient in other medicinal plants like Coptidis rhizoma and Berberidis Radix.

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Classification by use

• Therapeutic alkaloids
• Antimicrobial drugs
• Anti-inflammatory agents
• Anticancer compounds
• Antidiabetic substances

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• Chemicals used as pharmaceutical reference standards
• Chemicals used in quality control of traditional medicine

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel, Polymers, 2024, 16(16), 2368
2. Quantitative determination of coptisine and berberine hydrochloride in Corydalis conspersa by high-performance liquid chromatography and quality evaluation, Chinese Journal of Analytical Chemistry, Volume 53, Issue 10, October 2025, 100620