6485-79-6 | Triisopropylsilane (C₉H₂₁Si)

Chemical type

• Organosilane / Scavenger

Key properties

• Acts as a cation scavenger to prevent side reactions during deprotection
• Compatible with both TFA and MSA-based cocktails
• Used at low concentrations (e.g., 2.5%)

• Scavenger in cleavage cocktails for SPPS (e.g., TFA-TIS-H₂O or MSA-TIS-FA)
• Prevents alkylation or other side reactions during global deprotection
• Tested in synthesis of model peptides and APIs like tirzepatide

Classification by use

• Chemicals used as scavengers in peptide synthesis
• Auxiliary reagents in deprotection processes in SPPS

A trustworthy factory and manufacturer

1. Advancing sustainable peptide synthesis: methanesulfonic acid–formic acid as a greener substitute for TFA in final global deprotection, Green Chemistry, Volume 27, Issue 46, 7 November 2025, Pages 14911-14918