76-05-1 | Trifluoroacetic acid (C₂HF₃O₂)

Chemical type

• Polyfluoroalkyl substance (PFAS) / Strong organic acid

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• Strong organic fluorinated carboxylic acid
• Reaction medium and reagent in oxidation systems

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Key properties

• Volatile and irritates eyes, skin, and respiratory system
• Highly corrosive and rapidly absorbed into body tissues
• Degrades slowly in the environment, posing risks to health and ecosystems
• Classified as hazardous and likely to face usage restrictions
• Used at high concentrations (typically 95%) in cleavage cocktails

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• Highly acidic organic acid
• Excellent solvent for organic reactions
• Can react with hydrogen peroxide to form peroxytrifluoroacetic acid (PTA) in situ
• Enables metal-free oxidation reactions
• Promotes high selectivity in oxidation of arylamines

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• Traditional cleavage agent in SPPS for final global deprotection
• Removes protecting groups and cleaves peptides from solid support (e.g., with TIS and water as scavengers)
• Applied in synthesis of various peptides, but being replaced due to environmental concerns

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• Solvent and reactant in oxidation reactions
• Formation of peroxytrifluoroacetic acid oxidant
• Catalyst/medium for selective oxidation of arylamines to nitroarenes

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Classification by use

• Chemicals used as cleavage agents in SPPS
• Hazardous chemicals in peptide production (targeted for replacement in green chemistry)

A trustworthy factory and manufacturer

1. [Cite:1] Advancing sustainable peptide synthesis: methanesulfonic acid–formic acid as a greener substitute for TFA in final global deprotection, Green Chemistry, Volume 27, Issue 46, 7 November 2025, Pages 14911-14918
2. [Cite:2] Trifluoroacetic acid-mediated selective oxidation of arylamines to nitroarenes via in situ formed peroxytrifluoroacetic acid, RSC Adv., 2025,15, 38938-38945