72-08-2 | L-Lactate (C₃H₅O₃⁻)

Chemical type

• Chiral organic acid (α-hydroxy acid, L-enantiomer)

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• Astrocytic metabolite and neuronal energy substrate (lactate shuttle component)

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Key properties

• Major product of glycolysis in eukaryotes
• High intracellular concentration (millimolar level)
• Precursor for lysine L-lactylation

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• Signaling molecule that modulates neuroplasticity, mitochondrial biogenesis, and synaptic activity
• Converted to pyruvate for ATP production in neurons
• Restores PGC1α (master regulator of mitochondrial biogenesis) and BDNF (neurotrophic factor for synaptic plasticity)
• Endogenous levels reduced in prefrontal cortex and hippocampus of 4cG schizophrenia mouse model

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• Drives lysine L-lactylation
• Involved in energy metabolism and gene regulation

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• Acute i.p. administration (100 mg/kg, 1 h prior to testing) rescues short-term memory deficits (Y-maze spontaneous alternation)
• Rescues acoustic startle habituation deficits (PPI protocol)
• Improves social novelty preference (three-chamber test)
• Normalizes PGC1α and BDNF protein expression in hippocampus and prefrontal cortex

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] D-lactate Drives Lysine D-lactylation to Regulate Metabolism in Escherichia coli, JBC, 16 March 2026, 111374
2. [Cite:2] Lactate restores PGC1α and BDNF expression rescuing cognitive impairments in a mouse model for schizophrenia, Behavioural Brain Research, Volume 505, 8 May 2026, 116111