75-75-2 | Methanesulfonic Acid

Chemical type

• Organic acid
• Solvent for polymers

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• Strong organic acid

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Key properties

• Dissolves PEEK at room temperature (10 wt% dope solutions)
• Milder than sulfuric acid, resulting in minimal sulfonation (up to 4.6%) of PEEK during processing
• High purity (98%, MW 96.1 g mol⁻¹) for solution-based membrane fabrication
• Enables spinning of PEEK fibers without polymer modification

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• pKa of -1.86 (comparable to strong inorganic acids like nitric and sulfuric acid)
• Low vapor pressure and high boiling point
• Easily biodegradable (breaks down into sulfate and carbon dioxide)
• Greener and more environmentally friendly than Trifluoroacetic acid (TFA)
• Stronger acidity allows use at lower concentrations

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• Solvent in dope solutions for spinning PEEK hollow fibers using 3D-printed acid-resistant spinnerets
• Facilitates nonsolvent-induced phase separation (NIPS) process for membrane fabrication
• Allows control of membrane porosity by regulating coagulation conditions

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• Substitute for TFA in final global deprotection in solid-phase peptide synthesis (SPPS)
• Cleavage agent for removing protecting groups and detaching peptides from resin (e.g., RinkAmide resin)
• Used in combination with formic acid (FA) and triisopropylsilane (TIS) as a cleavage cocktail

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Classification by use

• Processing solvents for acid-soluble polymers
• Acids for polymer dissolution in membrane manufacturing

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• Chemicals used in green chemistry for peptide synthesis
• Chemicals used as cleavage agents in SPPS
• Chemicals promoting sustainability by replacing PFAS

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Molecular fractionation with poly(ether ether ketone) hollow fibers, Advanced Membranes, Volume 7, June 2026, 100193
2. [Cite:2] Advancing sustainable peptide synthesis: methanesulfonic acid–formic acid as a greener substitute for TFA in final global deprotection, Green Chemistry, Volume 27, Issue 46, 7 November 2025, Pages 14911-14918