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Cyanomethane

CAS No.: 75-05-8

  • Molecular Formula: CH3CN
  • Molecular Weight: 41.05 g/mol

Chemical type

  • Polar aprotic organic solvent
[1]
  • Polar aprotic organic solvent (nitrile)
[2]

Key properties

  • Permeance through PEEK membranes around 3 L m⁻² h⁻¹ bar⁻¹
  • Viscosity, molar diameter, kinetic diameter, and polar solubility parameter (δ_p) influence transport mechanisms (pore flow, solution-diffusion, friction)
  • Used in mixtures at 0.25 mM per solute for testing
  • Promotes higher rejection of small solutes compared to DMF in denser membranes
[1]
  • Protein precipitation solvent
  • High volatility
  • Compatible with LC-MS analysis
  • Miscible with water
[2]
  • Permeant for evaluating PEEK membrane performance in nanofiltration
  • Solvent for complex mixtures of 23 solutes (APIs, aromatics, dyes) in separation tests
  • Mobile phase in HPLC analysis for concentration measurements
[1]
  • Sample preparation solvent
  • Protein precipitation reagent
  • Mobile phase component in LC-MS
[2]

Classification by use

  • Test solvents for membrane characterization
  • Solvents in pharmaceutical and chemical separations
[1]
  • Chemicals used as analytical solvents
  • Chemicals used in chromatographic analysis
[2]

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  1. [Cite:1] Molecular fractionation with poly(ether ether ketone) hollow fibers, Advanced Membranes, Volume 7, June 2026, 100193
  2. [Cite:2] Transplacental passage of ampicillin: Implications for antenatal therapy, Placenta, Volume 175, 6 March 2026, Pages 66-72