Tiludronate disodium hemihydrate
CAS: 155453-10-4
Category: Inorganic Chemicals
| Purity | Pharmaceutical Grade ≥98.0%, High-Purity Grade ≥99.0%, Reference Standard Grade ≥99.5% |
| Molecular Formula | C8H9Na2O6PS·0.5H2O |
| Molecular Weight | 358.18 |
| Appearance | White to off-white crystalline powder, odorless or almost odorless |
| Packaging | 1 kg/aluminum foil bag, 5 kg/aluminum foil bag, 25 kg/fiber drum or HDPE container with inner liner |
| Testing Indicators | Appearance — Visual inspection; Identification — FTIR spectroscopy and 31P NMR; Assay/Purity — HPLC or ion chromatography; Water content — Karl Fischer titration; Residual solvents — GC according to ICH Q3C guidelines; Elemental impurities — ICP-MS/ICP-OES according to ICH Q3D; Sodium content — Atomic absorption spectroscopy or ICP; Related substances — HPLC impurity profiling; Loss on drying — Gravimetric method; Heavy metals — ICP-MS. |
| Storage Notes | Store in a cool, dry, and well-ventilated area. Keep container tightly closed and protected from moisture, heat, and direct sunlight. Store under controlled room temperature conditions (typically 15–25°C). Avoid contact with strong acids, strong bases, and oxidizing agents. Handle under clean and dry conditions to maintain pharmaceutical quality. |
| Lead Time | 10 days |
Tiludronate disodium hemihydrate is a nitrogen-free bisphosphonate compound used mainly as an active pharmaceutical ingredient (API) for bone metabolism regulation. It inhibits osteoclast-mediated bone resorption and is used in veterinary medicine for the treatment of bone disorders such as navicular disease and osteolysis in horses. It is also used as a research compound in studies related to osteoporosis, calcium metabolism, and bone remodeling.