Iomeprol
CAS: 78649-41-9
Category: Pharmaceutical Intermediates
| Purity | Reagent Grade ≥95%, Standard Grade ≥98%, High-Purity Grade ≥99%, Pharmaceutical Grade ≥98.0–102.0% ( |
| Molecular Formula | C17H22I3N3O8 |
| Molecular Weight | 777.09 |
| Appearance | White to off-white crystalline powder or solid |
| Packaging | 1 mg/glass vial, 5 mg/glass vial, 10 mg/glass vial, 25 mg/glass vial, 50 mg/glass vial, 100 mg/glass vial, 250 mg/glass vial, 1 g/glass vial, 5 g/glass vial, 25 g/HDPE bottle, or 1 kg/aluminum foil bag |
| Testing Indicators | Appearance — Visual inspection (white to off-white crystalline powder); Melting point — Capillary method (263–265°C, literature; 263–265°C, ChemicalBook); Boiling point — Distillation (813.2±65.0°C at 760 mmHg, predicted); Density — Hydrometer (d420 1.166–1.446, concentration-dependent; d437 1.161–1.441); Refractive index — Abbe refractometer (nD20 1.3828–1.4660, concentration-dependent); Purity — HPLC-UV (≥95–99.5%, C18 column, acetonitrile:buffer gradient, λ=220–254 nm); Related substances — HPLC (impurity profiling including impurity C (alkaline degradation product), des-iodo analogs, and other degradation products); Assay — RP-HPLC (linearity validated, recovery 90–110%, mass balance 90–110%); Loss on drying — Gravimetric (≤0.5%); Residue on ignition — Gravimetric (≤0.1%); Heavy metals — Colorimetric/ICP-MS (≤20 ppm); Iodine content — Titrimetric (theoretical: 48.99% w/w I); Identification — FTIR (characteristic peaks: N–H (amide) ~3300–3500 cm⁻¹, O–H (alcohol) ~3200–3400 cm⁻¹, aromatic C–H ~3000–3100 cm⁻¹, aliphatic C–H ~2850–2950 cm⁻¹, amide C=O ~1650–1680 cm⁻¹, C–O (alcohol) ~1050–1150 cm⁻¹, C–N ~1300–1350 cm⁻¹); UV spectrophotometry (λmax ~220–260 nm, triiodobenzene chromophore); ¹H NMR (DMSO-d₆: δ 2.80–3.20 ppm multiplet CH₂N (dihydroxypropyl), δ 3.40–3.80 ppm multiplet CH(OH) (dihydroxypropyl), δ 3.90–4.20 ppm multiplet CH₂OH (dihydroxypropyl), δ 4.80 ppm singlet CH₂OH (glycoloyl), δ 8.20 ppm broad singlet amide N–H); ¹³C NMR (DMSO-d₆: δ 40–45 ppm CH₂N, δ 60–65 ppm CH(OH), δ 65–70 ppm CH₂OH, δ 90–95 ppm CH₂OH (glycoloyl), δ 120–150 ppm aromatic carbons, δ 165–170 ppm amide C=O); Mass spectrometry — ESI-MS (m/z 778 [M+H]⁺, characteristic iodine isotope pattern); Water content — Karl Fischer titration (GB/T 6283/EP 2.5.12); pH — Potentiometry (aqueous solution, neutral, pH ~7.0 for formulated solutions); Specific optical rotation — Not applicable (achiral compound); Osmolality — Osmometer (low osmolality, ~413 mOsm/kg for 300 mgI/mL solution); Viscosity — Viscometer (low viscosity, ~4.6 mPa·s at 37°C for 300 mgI/mL solution). |
| Storage Notes | Store in a cool, dry, well-ventilated area at 2–8°C or -20°C. Protect from light, moisture, and air. Keep container tightly sealed. Store powder at -20°C for long-term stability (up to 3 years); at 4°C for 2 years. Light-sensitive material; avoid prolonged exposure to light and humid conditions. The formulated aqueous solution should be controlled at approximately pH 7.0 to ensure stability. Store away from strong oxidizing agents, strong bases, and incompatible substances. Use amber containers or light-protective wrapping for storage and transportation. |
| Lead Time | 10 days |
Iomeprol (INN, also known as Imeron, Iomeron, or Iomeprolo) is a non-ionic, triiodinated, water-soluble X-ray contrast medium (radiopaque agent) belonging to the benzenedicarboxamide class. It functions as a diagnostic aid for radiographic imaging by providing high radiopacity due to its three iodine atoms per molecule. Used as a pharmaceutical intermediate and active pharmaceutical ingredient (API) for the development and quality control of injectable contrast media formulations (e.g., Iomeron 300, Iomeron 350, Iomeron 400). Approved for clinical use in computed tomography (CT) scanning, urography, angiography, and other radiographic procedures requiring enhanced visualization of vascular structures and soft tissues. It exhibits very low osmolality and viscosity compared to ionic contrast agents, reducing the risk of adverse reactions. Also employed in analytical method development, forced degradation studies, and quality control applications. ATC code: V08AB10.