N-(3-Bromo-4-methylphenyl)-2-hydroxyiminoacetamide
CAS: 147149-83-5
Category: Organic Pharmaceutical Intermediates
| Purity | 97%-99% (HPLC); >=99% for pharmaceutical-grade material |
| Molecular Formula | C9H9BrN2O2 |
| Molecular Weight | 257.08 |
| Appearance | White powder |
| Packaging | 1 g/glass bottle, 5 g/glass bottle, 25 g/glass bottle, 100 g/glass bottle, 1 kg/foil bag, 10 kg/fiber drum, 25 kg/fiber drum |
| Testing Indicators | Appearance — Visual inspection; Identification — 1H NMR, FTIR, and mass spectrometry (MS); Purity — HPLC (area normalization, C18 column, UV detection at 254 nm); Water content — Karl Fischer titration; Melting point — Capillary melting point apparatus; Residual solvents — GC (headspace); Heavy metals — ICP-MS or atomic absorption spectroscopy; Related substances — HPLC gradient method. |
| Storage Notes | Store in a cool, dry, well-ventilated area away from heat and ignition sources. Keep container tightly closed when not in use. Protect from moisture and direct sunlight. Store under inert atmosphere (nitrogen or argon) if prolonged storage is required. Avoid contact with strong oxidizing agents, strong acids, and strong bases. |
| Lead Time | 10 days |
Key synthetic intermediate for the antitumor drug Nolatrexed Dihydrochloride (Tovetrex), a thymidylate synthase (TS) inhibitor. Used as a raw material for the production of targeted chemotherapeutic agents against colorectal cancer and head/neck tumors. Also used in pharmaceutical R&D for drug screening, pharmacodynamic evaluation, and pharmacokinetic studies. Further serves as a precursor for the synthesis of 6-bromo-5-methylisatin (CAS 306325-13-3).