Dacomitinib
CAS: 1110813-31-4
Category: Quinoline
| Purity | Research Grade ≥98%, High-Purity Grade ≥99%, Pharmaceutical Grade ≥99.5% |
| Molecular Formula | C24H25ClFN5O2 |
| Molecular Weight | 469.94 |
| Appearance | white to off-white crystalline powder |
| Packaging | 1 g/amber glass vial, 5 g/plastic bottle. |
| Testing Indicators | Appearance — Visual inspection; Identification — IR, LC-MS; Purity — RP-HPLC; Polymorphic form — XRPD; Residual solvents — HS-GC; Heavy metals — ICP-MS; Moisture — Karl Fischer titration; Microbial limits — Filtration; Quinazoline dimers — SEC. |
| Storage Notes | Stored at -20°C in a tightly closed container under inert atmosphere, away from light, heat, and humidity. |
| Lead Time | 10 days |
Used as an irreversible EGFR tyrosine kinase inhibitor intermediate in the synthesis of oral first-line therapies for EGFR-mutated non-small cell lung cancer.