122018-58-0 | Proteolipid Protein (PLP)139-151

Chemical type

• Synthetic peptide (amino acid sequence from proteolipid protein)

Key properties

• Immunogenic peptide used to induce autoimmune response
• Emulsified with complete Freund's adjuvant for immunization
• Leads to demyelination and neuroinflammation mimicking MS
• Administered subcutaneously at 200 µg dose
• Triggers relapse-remitting EAE in SJL/J mice

• Induction of experimental autoimmune encephalomyelitis (EAE) model
• Tool for studying multiple sclerosis (MS) pathogenesis
• Immunization agent in animal models of autoimmune diseases

Classification by use

• Chemicals used in disease model induction
• Chemicals used in immunological research
• Chemicals used as antigens/peptides in vaccines or models

A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. Mitogen-activated protein kinase inhibitor PD98059 improves neuroimmune dysfunction in experimental autoimmune encephalomyelitis in SJL/J mice through the inhibition of nuclear factor-kappa B signaling in B cells, Brain Research Bulletin, Volume 194, March 2023, Pages 45-53