128446-35-5 | Hydroxypropyl-β-Cyclodextrin (HPBCD)

Chemical type

• Modified cyclodextrin derivative

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• Chemically modified derivative of β-cyclodextrin (hydroxypropyl substitution at hydroxyl groups)

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Key properties

• Hydroxypropyl groups enhance water solubility
• Improved precipitation characteristics
• Hydrophobic cavity for inclusion complexes
• Biocompatible and suitable for aqueous environments

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• Improved water solubility and reduced toxicity compared to β-Cyclodextrin (β-CD)
• Amorphous state * Forms 1:1 inclusion complexes
• Higher stability constant (Kf) with Ethanamizuril (EZL) of 7436.41 M⁻¹
• Complexation efficiency (CE) of 0.22 * Stronger solubilizing effect than β-CD (increases EZL solubility up to 21.9-fold)

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• Soil remediation for persistent organic pollutants
• Enhances bioavailability in microbial and phytoremediation
• Pharmaceutical applications for drug solubility
• Removal of hydrophobic substances from contaminated sites

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• Solubilizing agent for poorly water-soluble drugs
• Enhances drug stability, permeability, dissolution, and bioavailability
• Forms inclusion complexes via hydrogen bonding and hydrophobic interactions
• Preferred for veterinary pharmacopoeia applications

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Classification by use

• Chemicals used in soil remediation
• Solubilizing agents in pharmaceuticals
• Enhancers for bioremediation

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• Pharmaceutical excipients

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Exploring the Efficacy of Methylated Gamma-Cyclodextrin (M-γ-CD) in the Removal of Heavy Metals in Soil Systems, Appl. Sci., 2025, 15(4), 2028
2. [Cite:2] Inclusion Complexes of Ethanamizuril with β- and Hydroxypropyl-β-Cyclodextrin in Aqueous Solution and in Solid State: A Comparison Study, Molecules, 2024, 29(10), 2164