142128-57-2 | Levoketoconazole

Chemical type

• Steroidogenesis inhibitor

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• Steroidogenesis inhibitor (2S,4R enantiomer of ketoconazole)

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Key properties

• Similar to ketoconazole, blocks multiple enzymes in adrenal steroidogenesis
• Potential hepatotoxicity and drug interactions

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• Inhibits cortisol synthesis
• Treats endogenous hypercortisolemia
• Associated with weight loss (e.g., 1.8 kg in 8 weeks, 5.1 kg in 6 months in clinical trials)
• Normalizes cortisol levels
• May cause tiredness and slight blood pressure drop

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• Medical therapy for Cushing syndrome

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• Treatment of Cushing’s syndrome in adults where surgery is not an option or ineffective
• Adjunct for mild hypercortisolism of unknown origin
• Combination therapy with GLP-1 agonists for enhanced weight loss

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Classification by use

• Medications for Cushing syndrome
• Steroidogenesis inhibitors

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• Medications used for hypercortisolism management
• Endocrine disorder treatments

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Osilodrostat for Cyclic Cushing Disease, AACE Endocrinology and Diabetes, Volume 13, Issue 1, January–February 2026, Pages 17-21
2. [Cite:2] Increased Weight Loss With the Combination of Levoketoconazole and Semaglutide in a Patient With Mild Hypercortisolism, AACE Endocrinology and Diabetes, Volume 12, Issue 3, September–October 2025, Pages 146-149