86386-73-4 | Fluconazole (C₁₃H₁₂F₂N₆O)

Chemical type

• Triazole antifungal

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• Antifungal agent
• Moderate CYP3A4 inhibitor

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Key properties

• Inhibits fungal ergosterol synthesis; broad-spectrum activity against Candida species

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• Increases plasma concentrations of CYP3A4-metabolized drugs
• Administered as loading dose (400 mg) followed by maintenance (200 mg QD)
• Well-known for drug-drug interactions with CYP3A substrates

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• Prevention or treatment of fungal infections; part of supportive therapy to manage potential infections in SJS patient

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• Antifungal treatment
• Inhibitor of CYP3A4 to study pharmacokinetic interactions

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Classification by use

• Antifungal agents for infection control
• Drugs for supportive care in hypersensitivity

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• Antifungal drugs
• CYP enzyme inhibitors
• Pharmacokinetic interaction probes

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Stevens-Johnson syndrome triggered by phenytoin in a patient with type 2 diabetes and seizures, Exploratory Research in Clinical and Social Pharmacy, Volume 19, September 2025, 100624
2. [Cite:2] Pharmacokinetic interaction between SHR2554 and fluconazole: A single-center, open-label and one-sequence crossover phase I trial in healthy Chinese subjects, European Journal of Pharmaceutical Sciences, Volume 212, 1 September 2025, 107163