167869-21-8 | PD98059

Chemical type

• Specific ERK inhibitor
• Small molecule MEK1/2 inhibitor

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• Mitogen-activated protein kinase (MAPK) inhibitor (specifically targets ERK1/2 pathway)

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Key properties

• Suppresses ERK activation and phosphorylation
• Reduces SU11274-induced autophagy, p53 activation, and Bcl-2 phosphorylation
• Decreases SU11274-mediated cell death and autophagic markers (Beclin-1, LC3-II)
• Used at micromolar concentrations (e.g., 5 µM)

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• Potent inhibitor of MAPK signaling
• Reduces NF-κB p65 activation and increases IκBα expression
• Suppresses production of inflammatory mediators (e.g., CCR6, CD14, GM-CSF, iNOS, IL-6, TNF-α) in B cells and brain tissue
• Administered at 5 mg/kg intraperitoneally in DMSO vehicle
• Ameliorates neuroimmune dysfunction in EAE model without reported toxicity in study

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• Inhibitor of MAPK/ERK pathway in cancer signaling studies
• Tool to dissect ERK's role in autophagy and apoptosis

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• Therapeutic agent for experimental autoimmune encephalomyelitis (EAE) in mice
• Potential treatment for multiple sclerosis (MS) by modulating neuroinflammation
• Suppresses inflammatory cytokine expression in spleen and brain
• Administered daily from day 14 to 28 post-EAE induction

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Classification by use

• Chemicals used as kinase inhibitors
• Chemicals used in signal transduction research

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• Chemicals used as kinase inhibitors
• Chemicals used in autoimmune disease treatment
• Chemicals used in neuroinflammation modulation

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Activation of ERK–p53 and ERK-Mediated Phosphorylation of Bcl-2 Are Involved in Autophagic Cell Death Induced by the c-Met Inhibitor SU11274 in Human Lung Cancer A549 Cells, Journal of Pharmacological Sciences, Volume 118, Issue 4, 2012, Pages 423-432
2. [Cite:2] Mitogen-activated protein kinase inhibitor PD98059 improves neuroimmune dysfunction in experimental autoimmune encephalomyelitis in SJL/J mice through the inhibition of nuclear factor-kappa B signaling in B cells, Brain Research Bulletin, Volume 194, March 2023, Pages 45-53