30562-34-6 | Geldanamycin

Chemical type

• Natural Hsp90 inhibitor
• Ansamycin antibiotic

^[1]

• Benzoquinone ansamycin

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Key properties

• Binds to ATP pocket and competes with ATP
• High affinity in cancer cells
• Limited clinical activity due to toxicity

^[1]

• Naturally occurring from Streptomyces hygroscopicus
• Inhibitor of Hsp90
• Antibacterial properties
• Inhibits RNA-dependent DNA polymerases
• Poor solubility and stability
• Unacceptable liver toxicity
• Biosynthesized via polyketide pathway
• Unique benzoquinone ring reactivity at C-17 and C-19

^[2]

• Hsp90 inhibitor
• Basis for analogs like 7-AAG in anti-cancer research

^[1]

• Lead compound for medicinal chemistry
• Drug discovery in oncology
• Potential applications in HIV/AIDS, malaria, and neurodegenerative diseases

^[2]

Classification by use

• Anti-cancer agents targeting molecular chaperones
• Natural products for protein inhibition

^[1]

• Hsp90 inhibitors
• Anticancer agents
• Antibacterial agents

^[2]

A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Exploring the inhibitory mechanism of resorcinylic isoxazole amine NVP-AUY922 towards the discovery of potential heat shock protein 90 (Hsp90) inhibitors, Scientific African, Volume 15, March 2022, e01107
2. [Cite:2] Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry, Journal of Medicinal Chemistry, Volume 67, Issue 20, 24 October 2024, Pages 17946-17963