320-67-2 | 5-Azacytidine

Chemical type

• Nucleoside analog (cytidine analog)

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• DNA methyltransferase inhibitor

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Key properties

• DNA methylation inhibitor
• Induces hypomethylation by replacing cytosine during DNA replication
• Covalently binds to DNA methyltransferases (DNMTs)
• Concentration-dependent effects: enhances antioxidant enzyme activity at low levels (e.g., 50 µM), promotes secondary metabolite accumulation at higher levels (e.g., 200 µM)
• Can cause physiological stress like leaf yellowing at excessive concentrations

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• Induces DNA demethylation
• Inhibits DNA methyltransferases (DNMTs)
• Promotes gene reactivation

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• Epigenetic regulator to modulate gene expression in plants
• Promotes biosynthesis of secondary metabolites like patchoulol and pogostone
• Alleviates environmental stresses (e.g., salt, aluminum) in plants
• Induces traits like embryogenesis, flowering, and stress tolerance in research

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• Pharmacological tool to study DNA demethylation
• Investigates effects on beige adipocyte differentiation and function
• Enhances thermogenic gene expression (e.g., Ucp1, Cox7a1)
• Increases mitochondrial function and fatty acid uptake

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Classification by use

• Chemicals used in epigenetic modulation
• Chemicals used in plant secondary metabolism enhancement
• Chemicals used in stress tolerance induction

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• Chemicals used in epigenetic research
• Chemicals used in metabolic disease research (obesity, type 2 diabetes)

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] 5-AzaC promotes the synthesis of patchoulol and pogostone in Pogostemon cablin by regulating DNA methylation, Scientia Horticulturae, Volume 351, September 2025, 114410
2. [Cite:2] DNA methyltransferase inhibition by 5-azacytidine promotes thermogenic programming in beige adipocytes, Biochemical and Biophysical Research Communications, Volume 774, 8 August 2025, 152094