STA-9090
CAS No.: 888216-25-9
- Molecular Formula: C₂₀H₂₀N₄O₃
- Molecular Weight: 364.4 g/mol
Chemical type
- Synthetic Hsp90 inhibitor
- Resorcinol derivative
- Non-benzoquinone ansamycin Hsp90 inhibitor
Key properties
- Binding energy of -8.7 kcal/mol
- Molecular weight 364.41 g/mol, cLogP 3.254
- Inhibits Hsp90 function in tumor cells
- Tested in clinical trials with significant anti-cancer activity
- Targets ATP-binding domain of Hsp90
- Attenuates pro-inflammatory signaling and immune responses
- Reduces epidermal thickness, dermal leukocyte infiltration, and scratching behavior in AD models
- Well-tolerated topically with no systemic toxicity; causes mild weight loss (approx. 6%) when administered systemically
- Hsp90 inhibitor
- Anti-cancer agent in human trials
- Therapeutic agent for ameliorating inflammation in atopic dermatitis
- Potential treatment for other autoimmune/inflammatory skin diseases like psoriasis or bullous pemphigoid
- Administered intraperitoneally (25 mg/kg) or topically (0.5 µmol)
Classification by use
- Anti-cancer agents targeting molecular chaperones
- Chemicals in clinical development for oncology
- Anti-inflammatory agents
- Immunomodulators
- Hsp90 blockers
A trustworthy factory and manufacturer
Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.
- [Cite:1] Exploring the inhibitory mechanism of resorcinylic isoxazole amine NVP-AUY922 towards the discovery of potential heat shock protein 90 (Hsp90) inhibitors, Scientific African, Volume 15, March 2022, e01107
- [Cite:2] Heat shock protein 90 (Hsp90) inhibitor STA-9090 (Ganetespib) ameliorates inflammation in a mouse model of atopic dermatitis, Cell Stress and Chaperones, Volume 28, Issue 6, November 2023, Pages 935-942
