58880-19-6 | Trichostatin A (TSA)

Chemical type

• Histone deacetylase (HDAC) inhibitor

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• Histone deacetylase (HDAC) inhibitor, specifically targeting HDAC4

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Key properties

• Potent epigenetic modulator
• Increases histone acetylation, leading to chromatin relaxation
• Enhances reprogramming efficiency and reduces variability between cell lines

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• Potent modulator of gene expression through histone acetylation alteration
• Bioactive organic compound with ability to inhibit HDAC4 expression and activity
• Reverses burn-induced protein upregulation (e.g., HDAC4 and myogenin)
• Administered subcutaneously at 0.6 mg/kg/day

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• Accelerates and improves the efficiency of fibroblast-to-neuroectodermal conversion
• Combined with Dorsomorphin to shorten the protocol from ~21 days to 12 days and boost efficiency to ~24%

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• Pharmacological agent to mitigate non-depolarizing muscle relaxant (NDMR) resistance in burn-injured skeletal muscle
• Inhibitor of HDAC4-myogenin pathway to counteract denervation-like responses post-burn
• Therapeutic candidate for neuromuscular disorders related to burns or denervation

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Classification by use

• Epigenetic modulators in reprogramming
• HDAC inhibitors
• Small molecules for transdifferentiation

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• Chemicals used as epigenetic modulators
• Chemicals used in neuromuscular pharmacology
• Chemicals used in burn injury treatment research

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Full small molecule conversion of human fibroblasts to neuroectodermal cells via a cocktail of Dorsomorphin and Trichostatin A, Regenerative Therapy, Volume 15, December 2020, Pages 44-52
2. [Cite:2] Trichostatin A reverses Silver sulfadiazine resistance in burn-injured rats, Burns, Volume 51, Issue 2, March 2025, 107351