63527-52-6 | Cefotaxime

Chemical type

• β-lactam antibiotic
• Third-generation cephalosporin

Key properties

• Broad-spectrum activity against Gram-negative and some Gram-positive bacteria
• Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)

• Broad spectrum activity against aerobic Gram-negative and Gram-positive bacteria
• Variable activity against anaerobic bacteria
• Maximum concentration in shrimp hepatopancreas: 19.45 ± 2.10 mg/kg at 1 hour post-administration
• Maximum concentration in shrimp plasma: 0.184 ± 0.061 mg/L at 4 hours post-administration
• Elimination half-life in shrimp: Approximately 23 hours above MIC for Vibrio parahaemolyticus
• Potential negative effects on hepatopancreas histology, including oxidation stress and changes in intestinal cell morphology
• Withdrawal time: 8.5 degree-days (once-daily dosing) or 95.5 degree-days (twice-daily dosing) based on MRL of 50 µg/kg in shrimp muscle

• Positive control in antibacterial assays
• Clinical treatment of infections (UTI, pneumonia, sepsis, CNS)

• Treatment of bacterial infections in aquaculture, including AHPND in white leg shrimp caused by Vibrio parahaemolyticus
• Control of susceptible bacterial pathogens in tilapia and other aquatic animals
• Disease management in shrimp farming via oral administration at 25 mg/kg body weight

Classification by use

• Antibiotic / Antimicrobial agent
• Positive control in biological assays

• Antibiotics used in aquaculture disease control

A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Biogenic synthesis of silver nanoparticles using cell-free extracts of thermotolerant bacteria: Antioxidant and antibacterial properties, Electronic Journal of Biotechnology, Volume 79, January 2026, 100698
2. [Cite:2] Pharmacokinetics and Withdrawal Times of Cefotaxime in White Leg Shrimp (Litopenaeus vannamei) after Oral Administration, Fishes, 2024, 9(6), 232