76-74-4 | Pentobarbital

Chemical type

• Barbiturate anesthetic

^[1,2]

• Barbiturate (Organic compound)

^[3]

Key properties

• Induces anesthesia at 100 mg/kg intraperitoneally
• Maintains anesthesia depth with intermittent administration

^[1]

• Short-acting sedative, induces deep anesthesia at 200 mg/kg i.p., used for euthanasia and perfusion

^[2]

• Central nervous system depressant; anesthetic and sedative

^[3]

• Anesthetic for establishing burn injury models in rats
• Facilitates surgical procedures like tracheotomy and muscle tension assays

^[1]

• Anesthetic for terminal procedures like transcardial perfusion in Experimental autoimmune encephalomyelitis (EAE) studies

^[2]

• Intraperitoneal injection (3%) for surgical anesthesia in mice during MCAO-HT procedure; used for euthanasia

^[3]

Classification by use

• Chemicals used as anesthetics
• Chemicals used in animal model surgeries

^[1]

• Anesthetics in animal research

^[2]

A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Trichostatin A reverses Pentobarbital resistance in burn-injured rats, Burns, Volume 51, Issue 2, March 2025, 107351
2. [Cite:2] EAE models of neuropathic pain in multiple sclerosis do not require pertussis toxin, Brain Research, Volume 1875, 15 March 2026, 150162
3. [Cite:3] Proteoglycan 4 attenuates ischemic post-stroke hemorrhagic transformation and blood-brain barrier disruption, IBRO Neuroscience Reports, Volume 19, December 2025, Pages 661-667