199062-33-4 | Pertussis Toxin

Chemical type

• Bacterial protein toxin (from Bordetella pertussis)

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• Bacterial protein toxin

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• Bacterial toxin
• Gαi protein inhibitor

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Key properties

• Enhances autoimmune response by disrupting blood-brain barrier
• Administered intraperitoneally at 200 ng dose
• Facilitates CNS infiltration by immune cells in EAE
• Contributes to EAE symptom onset and severity

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• ADP-ribosylates G proteins, disrupts blood-brain barrier integrity, enhances immune cell infiltration into the CNS, increases EAE disease severity in a concentration-dependent manner

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• ADP-ribosylates Gαi subunits
• Inhibits Gαi-mediated signaling
• Did not affect (R)-(-)-carvone-evoked calcium responses

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• Adjuvant in EAE induction protocol
• Tool for modeling neuroinflammatory diseases like MS
• Administered on day of immunization to potentiate encephalitogenic effects

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• Adjuvant to supplement MOG and CFA in inducing EAE models of multiple sclerosis, promotes autoimmune encephalomyelitis pathology

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• Research tool for identifying Gαi involvement
• Inhibitor in GPCR signaling studies

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Classification by use

• Chemicals used as toxins in disease models
• Chemicals used in immunological adjuvants
• Chemicals used in autoimmune research

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• Immunomodulatory agents in preclinical autoimmune disease models

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• Bacterial toxins
• G protein inhibitors

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Mitogen-activated protein kinase inhibitor PD98059 improves neuroimmune dysfunction in experimental autoimmune encephalomyelitis in SJL/J mice through the inhibition of nuclear factor-kappa B signaling in B cells, Brain Research Bulletin, Volume 194, March 2023, Pages 45-53
2. [Cite:2] EAE models of neuropathic pain in multiple sclerosis do not require pertussis toxin, Brain Research, Volume 1875, 15 March 2026, 150162
3. [Cite:3] The odorant (R)-(-)-carvone promotes glucose-stimulated insulin secretion via the olfactory receptor Olfr1259 in pancreatic β-TC6 cells, Archives of Biochemistry and Biophysics, Volume 768, June 2025, 110404