88899-55-2 | Bafilomycin A1 (Baf-A1)

Chemical type

• Lysosomal inhibitor (V-ATPase inhibitor)

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• Macrolide antibiotic

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Key properties

• Inhibits vacuolar H+-ATPase
• Increases RDH5 accumulation in lysosomes
• Enhances colocalization of RDH5 with LAMP1
• Restores RDH5 levels in HSP90-deficient cells

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• Specific inhibitor of vacuolar proton-translocating ATPase; disrupts fungal growth and virulence.

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• Blocks autolysosomal degradation in RPE cells
• Studies protein translocation and degradation in visual cycle
• Inhibits lysosomal function in autophagy research

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• Investigated for its ability to inhibit Candida albicans growth and disrupt the structure and function (e.g., acid production, biofilm formation) of C. albicans-Streptococcus mutans dual-species biofilms. Potential application in preventing dental caries and fungal infections.

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Classification by use

• Chemicals used as macrolide antibiotics (original)
• Chemicals used as autophagy/lysosome inhibitors

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• Chemicals used in antimicrobial research

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] HSP90 stabilizes visual cycle retinol dehydrogenase 5 in the endoplasmic reticulum by inhibiting its degradation during autophagy, JBC, Volume 301, Issue 2, February 2025, 108126
2. [Cite:2] Bafilomycin A1 Inhibits The Candida Albicans-Streptococcus Mutans Biofilm, International Dental Journal, Volume 75, Supplement 1, October 2025, 104544