54-05-7 | Chloroquine (CQ)

Chemical type

• Lysosomal inhibitor

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• 4-Aminoquinoline compound

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Key properties

• Inhibits lysosomal acidification
• Restores RDH5 protein levels in HSP90-deficient or IPI-504-treated cells
• Increases SQSTM1/P62 and LC3-II accumulation
• Enhances RDH5-SQSTM1/P62 interaction

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• Autophagy inhibitor (impairs lysosomal function and autophagosome-lysosome fusion)
• Exhibits synergistic cytotoxicity when combined with other agents
• Can increase autophagosome accumulation
• Induces apoptosis (caspase-3/7 activity)

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• Blocks lysosomal degradation in RPE cells
• Studies autophagy-lysosomal pathway for protein stability
• Rescues downregulation of visual cycle proteins

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• Used to inhibit autophagy and sensitize cancer cells to photodynamic therapy
• Enhances the efficacy of IR-783-based PDT

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Classification by use

• Chemicals used as antimalarial agents (original use)
• Chemicals used as lysosomal inhibitors in research

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• Chemicals used as autophagy inhibitors
• Chemicals used as anticancer adjuvants

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] HSP90 stabilizes visual cycle retinol dehydrogenase 5 in the endoplasmic reticulum by inhibiting its degradation during autophagy, JBC, Volume 301, Issue 2, February 2025, 108126
2. [Cite:2] Enhancement of photodynamic reaction by chloroquine through apoptosis induction, lipid peroxidation augmentation, and autophagy inhibition using IR-783, Journal of Photochemistry and Photobiology B: Biology, Volume 271, October 2025, 113242