5142-23-4 | 3-Methyladenine (3-MA)

Chemical type

• Autophagy inhibitor
• Small molecule PI3K inhibitor

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• Autophagy inhibitor

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Key properties

• Blocks autophagy by inhibiting class III PI3K
• Reduces SU11274-induced autophagic ratio, Beclin-1 expression, and LC3 conversion
• Decreases SU11274-mediated cell death, indicating protective role against autophagic cytotoxicity
• Used at millimolar concentrations (e.g., 0.4 mM)

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• Inhibits autophagosome formation
• Suppresses NF-κB signaling pathway
• Reduces IL-6 levels and macrophage recruitment
• Administered intraperitoneally at 10 mg/kg/day
• Alleviates colitis severity in aged models

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• Tool to inhibit autophagy in cancer research
• Agent to study autophagy's role in cell death and survival

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• Pharmacological treatment for DSS-induced colitis in aged mice
• Inhibits excessive autophagy in intestinal epithelial cells
• Mitigates inflammation in elderly ulcerative colitis models

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Classification by use

• Chemicals used as autophagy inhibitors
• Chemicals used in cell death mechanism studies

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• Chemicals used as autophagy modulators
• Chemicals used in anti-inflammatory therapy for IBD

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Activation of ERK–p53 and ERK-Mediated Phosphorylation of Bcl-2 Are Involved in Autophagic Cell Death Induced by the c-Met Inhibitor SU11274 in Human Lung Cancer A549 Cells, Journal of Pharmacological Sciences, Volume 118, Issue 4, 2012, Pages 423-432
2. [Cite:2] Autophagy inhibitor 3-methyladenine mitigates the severity of colitis in aged mice by inhibiting autophagy, Experimental Gerontology, Volume 201, March 2025, 112697