2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl
CAS: 213697-53-1
Category: Organic Pharmaceutical Intermediates
| Purity | Catalyst Grade ≥98%; Research Grade ≥99%; HPLC Grade ≥99% |
| Molecular Formula | C26H36NP |
| Molecular Weight | 393.54 |
| Appearance | White to pale yellow crystalline powder |
| Packaging | 1 g, 5 g, 10 g, 25 g, 100 g amber glass bottle or fluorinated bottle; customized bulk packaging available |
| Testing Indicators | Appearance — Visual inspection; Identification — ¹H NMR, ¹³C NMR and ³¹P NMR; Molecular weight — HRMS or LC-MS; Purity — HPLC (UV) and/or GC; Phosphine oxide impurity — ³¹P NMR or HPLC; Water content — Karl Fischer titration (GB/T 6283); Residual solvents — GC (ICH Q3C); Melting point — Capillary melting point determination; Elemental analysis — CHN elemental analysis. |
| Storage Notes | Store in a tightly sealed container under nitrogen or argon in a cool, dry, well-ventilated area. Protect from moisture, oxygen, direct sunlight, and heat. Recommended storage temperature is 2–8°C for long-term storage. Minimize exposure to air during handling to prevent oxidation. |
| Lead Time | 10 days |
A sterically hindered, electron-rich biaryl monophosphine ligand extensively used in palladium-catalyzed cross-coupling chemistry. Commonly employed for Buchwald-Hartwig amination, Suzuki-Miyaura coupling, Negishi, Kumada, Stille, and other C-C/C-N bond-forming reactions. Frequently used in pharmaceutical, agrochemical, and fine chemical process development as a high-performance catalyst ligand.