2-di-tert-butylphosphino-2'-(N,N-dimethylamino)biphenyl
CAS: 224311-49-3
Category: Organic Pharmaceutical Intermediates
| Purity | Research Grade ≥97%; Catalyst Grade ≥98%; High-Purity Grade ≥99% |
| Molecular Formula | C24H34NP |
| Molecular Weight | 367.51 |
| Appearance | White to off-white crystalline powder or pale yellow solid |
| Packaging | 1 g, 5 g, 10 g, 25 g, 100 g amber glass bottle or aluminum foil bag under inert atmosphere |
| Testing Indicators | Appearance — Visual inspection; Identification — ¹H NMR, ¹³C NMR and ³¹P NMR; Molecular weight confirmation — HRMS/LC-MS; Purity — HPLC or GC (where applicable); Phosphorus assay — ³¹P NMR; Water content — Karl Fischer titration (GB/T 6283); Residual solvents — GC (ICH Q3C); Melting range — Capillary melting point; Elemental analysis — CHN; Heavy metals — ICP-MS. |
| Storage Notes | Store in a tightly sealed container under nitrogen or argon in a cool, dry, well-ventilated place. Protect from air, moisture, heat, and direct sunlight. Refrigerated storage (2-8°C) under inert atmosphere is recommended for long-term stability. Avoid prolonged exposure during handling. |
| Lead Time | 10 days |
A sterically hindered electron-rich biaryl monophosphine ligand widely employed in palladium-catalyzed cross-coupling reactions including Buchwald-Hartwig amination, Suzuki-Miyaura, Negishi, Stille, and Kumada coupling reactions. Commonly used as a ligand in pharmaceutical, fine chemical, and process development for highly active Pd catalyst systems.