(2',6'-Dimethoxy-[1,1'-biphenyl]-2-yl)diphenylphosphine
CAS: 819867-24-8
Category: Organic Pharmaceutical Intermediates
| Purity | Research Grade ≥97%; Catalyst Grade ≥98%; High-Purity Grade ≥99% |
| Molecular Formula | C26H23O2P |
| Molecular Weight | 398.43 |
| Appearance | White to pale yellow crystalline powder |
| Packaging | 1 g, 5 g, 10 g, 25 g, 100 g amber glass bottle or aluminum foil bag under nitrogen |
| Testing Indicators | Appearance — Visual inspection; Identification — ¹H NMR, ¹³C NMR and ³¹P NMR; Molecular weight confirmation — HRMS or LC-MS; Purity — HPLC or GC; Phosphorus identity — ³¹P NMR; Water content — Karl Fischer titration (GB/T 6283); Residual solvents — GC (ICH Q3C); Melting point — Capillary melting point apparatus; Elemental analysis — CHN; Heavy metals — ICP-MS. |
| Storage Notes | Store tightly sealed under nitrogen or argon in a cool, dry, well-ventilated place. Protect from moisture, oxygen, direct sunlight, and heat. Refrigerated storage at 2-8°C under inert atmosphere is recommended for long-term stability. Minimize exposure to air during handling. |
| Lead Time | 10 days |
A sterically hindered electron-rich biaryl phosphine ligand widely employed for the preparation of palladium catalyst systems. Commonly used in Buchwald-Hartwig amination, Suzuki-Miyaura, Negishi, Kumada, Stille, and other transition-metal-catalyzed cross-coupling reactions for pharmaceutical, agrochemical, and fine chemical synthesis. Also utilized in catalyst development and organometallic research.