Tivozanib

CAS: 475108-18-0

Category: Kinase Inhibitors

PurityReagent Grade ≥98%, High-Purity Grade ≥99%, Technical Grade ≥95%
Molecular FormulaC22H19ClN4O5
Molecular Weight454.86
Appearancewhite to off-white crystalline powder
Packaging1 g/amber glass vial, 5 g/plastic bottle.
Testing IndicatorsAppearance — Visual inspection; Identification — IR, LC-MS; Purity — Gradient RP-HPLC; Polymorphic form — XRPD; Residual solvents — HS-GC; Heavy metals — ICP-MS; Moisture — Karl Fischer titration; Microbial limits — Membrane filtration; VEGFR impurities — SEC.
Storage NotesStored at -20°C in a tightly closed container under inert atmosphere, protected from light, moisture, and oxidizing agents.
Lead Time
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days
Used as a VEGFR tyrosine kinase inhibitor intermediate in the synthesis of oral targeted therapies for advanced renal cell carcinoma.