9011-18-1 | Dextran Sulfate Sodium

Chemical type

• Sulfated polysaccharide

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• Sulfated polysaccharide

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• Polysaccharide
• Chemical irritant

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Key properties

• Induces acute colitis mimicking ulcerative colitis
• Administered at 2% in drinking water for 7 days
• Increases autophagy activity in aged models
• Causes body weight loss, higher DAI scores, and colon damage

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• Induces colonic inflammation; disrupts intestinal epithelial barrier

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• Heparin-like polysaccharide with sulfate groups
• Induces intestinal inflammation by impairing epithelial integrity

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• Induction of experimental colitis model in mice
• Study of autophagy and inflammation in young vs. aged subjects

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• Combined with Azoxymethane (AOM) to generate inflammation-driven colorectal cancer models in mice

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• Experimental induction of acute colitis in mouse models
• Tool to study intestinal barrier function and inflammation
• Used to evaluate the protective effects of propionate and Bacteroides against colitis

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Classification by use

• Chemicals used in animal models for inflammatory bowel disease
• Chemicals used in pathogenesis research for UC

A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] Autophagy inhibitor 3-methyladenine mitigates the severity of colitis in aged mice by inhibiting autophagy, Experimental Gerontology, Volume 201, March 2025, 112697
2. [Cite:2] Intratumoral microbiota-derived S1P sensitizes the combination therapy of capecitabine and PD-1 inhibitors, Iscience, Volume 28, Issue 12, 19 December 2025, 114202
3. [Cite:3] Bacteroides methylmalonyl-CoA mutase produces propionate that promotes intestinal goblet cell differentiation and homeostasis, Cell Host Microbe, Volume 32, Issue 1, 10 January 2024, Pages 63-78.e7