2323027-38-7 | Ceapin-A7 (C₂₀H₁₂F₆N₄O₃)

Chemical type

• ATF6 inhibitor
• Pharmacologic modulator

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• Small-molecule ATF6 inhibitor
• Selective ER stress pathway inhibitor

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Key properties

• Prevents ATF6 (Activating Transcription Factor 6) transport to the Golgi apparatus
• Acts as an ATF6 inhibitor during ER stress
• Impairs endothelial barrier integrity

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• Inhibits ATF6 activation
• Prevents ATF6 trafficking to the Golgi apparatus
• Decreases CTGF expression
• Increases inflammatory cytokine expression
• Used at micromolar concentrations (5 μM in study)

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• Experimental tool to study ATF6 function
• Used in this study to investigate the role of ATF6 in mediating the protective effects of Pasireotide

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• Experimental ATF6 inhibitor
• Tool compound to suppress ATF6-mediated transcription
• Used to investigate ER stress signaling mechanisms

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] ATF6 inhibition suppresses the protective effects of pasireotide in human and bovine endothelial cells, Vascular Biology, Volume 7, Issue 1, 1 January 2025
2. [Cite:2] CTGF regulated by ATF6 inhibits vascular endothelial inflammation and reduces hepatic ischemia–reperfusion injury, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1870, Issue 8, December 2024, 167490