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CasNo： 527-73-1
MF： C3H3N3O2
Appearance： pale yellow solid
| Description | 2-Nitroimidazole is a chemical compound that belongs to the class of nitroimidazoles, characterized by a nitro group attached to an imidazole ring. 2-Nitroimidazole is an organic compound with important chemical properties. It has certain applications in the fields of medicine and chemical research. |
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Uses |
2-Nitroimidazole is primarily known for its use as a radiosensitizer in cancer therapy, where it enhances the effectiveness of radiation treatment by selectively targeting hypoxic tumor cells, which are often resistant to radiation. Beyond its medical applications, 2-nitroimidazole is also utilized in the development of anti-infective agents, particularly against anaerobic bacteria and protozoa. Its mode of action typically involves the reduction of the nitro group under anaerobic conditions, leading to the formation of reactive intermediates that can damage cellular components. |
| Supplier | DEMEI ELECTRONIC COMMERCE FIRM was established in 2024 and is located in Yiwu, Zhejiang Province. Although it was established not long ago, it has more than ten years of industry experience. The affiliated factory covers an area of 7,000 square meters. In addition, it also has its own excellent reserve of talents. Our high-tech R&D team, workshop production and sales R&D personnel have exceeded 200 people. In recent years, our products have also been exported to the UK, Germany, Australia, the Netherlands, Poland, Russia, Kazakhstan, the Philippines, Malaysia, Singapore and many other regions. , we do business with customers based on the principle of honesty and trustworthiness. We work for customer satisfaction and achieve the greatest recognition from customers within the scope permitted by law. We focus on every detail and strive to provide customers with procurement, research and development, quality control, Grasp the best service in terms of safe transportation, so as to establish long-term cooperative relationships with customers. |
InChI:InChI=1/C3H3N3O2/c7-6(8)3-4-1-2-5-3/h1-2H,(H,4,5)
Racemic misonidazole, a radiosensitizer ...
Chagas disease affects 6–8 million peopl...
2-Nitroimidazoles are the group of bioreductive prodrugs which are developed toward their application in diagnosis and therapy of hypoxic tissues characteristic of tumors [15]. Pimonidazole (α-((2-nitroimidazol-1-yl)methyl)-1-piperidineethanol) has been commonly applied for the detection and quantification of hypoxia...
2-aminoimidazole hemisulfate
2-nitro-1H-imidazole
| Conditions | Yield |
|---|---|
|
2-aminoimidazole hemisulfate; With sodium nitrate; sulfuric acid; In water; at 0 ℃; for 0.5h;
With copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; sodium nitrite; In water; at 50 ℃; for 2h;
|
68% |
|
2-aminoimidazole hemisulfate; With tetrafluoroboric acid; sodium nitrite; In water; for 0.5h;
With copper(II) sulfate; In water; at -5 - 20 ℃; for 24h;
|
32% |
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2-aminoimidazole hemisulfate; With copper(ll) sulfate pentahydrate; In water; at -20 - 20 ℃;
With sodium nitrite; In water; at -10 - 20 ℃;
With ammonia; In water; at -20 - 0 ℃; pH=1;
|
2-aminoimidazolesulfate
2-nitro-1H-imidazole
| Conditions | Yield |
|---|---|
|
2-aminoimidazolesulfate; With sodium nitrite; In tetrafluoroboric acid; water; acetone; at -20 - -10 ℃;
With copper(II) sulfate; sodium nitrite; In tetrafluoroboric acid; water; acetone; at 20 ℃; for 2h;
|
65% |
1H-imidazol-2-amine
N-tritylimidazole
2-aminoimidazolesulfate
2-bromo-1H-imidazole
2-acetamidoimidazole
4-Morpholinomethyl-2-nitro-imidazol
2-nitro-4(5)-N-pyrrolidinomethylimidazole
1-(2-hydroxy-3-buten-1-yl)-2-nitroimidazole
