528-48-3 | Fisetin

Chemical type

• Flavonol (flavonoid)

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• Natural flavonoid (Flavonol subclass)
• Plant-derived polyphenolic compound

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Key properties

• Reverses cognitive decline
• Targets Aβ plaque buildup, tau hyperphosphorylation, neuroinflammation, and oxidative stress

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• Antioxidant activity (ROS scavenger)
• Anti-inflammatory activity
• Anti-apoptotic activity
• Modulates PI3K/Akt/mTOR signaling pathway
• Enhances autophagy
• Reduces α-synuclein aggregation
• Mitochondrial membrane protection
• Blood–brain barrier permeable
• Senolytic activity
• Dissolvable in organic solvents (ethanol, DMSO, DMF)

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• Cognitive enhancement in Alzheimer's mouse models
• Multi-targeted therapeutic for Alzheimer's pathological features

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• Neuroprotective agent in Parkinson’s disease models
• Modulator of PI3K/Akt/mTOR signaling
• Autophagy enhancer
• Anti-inflammatory therapeutic candidate
• Antioxidant agent
• Mitochondrial protective agent
• Adjunct candidate to levodopa therapy
• Potential disease-modifying therapy in neurodegeneration

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Classification by use

• Chemicals used as cognitive enhancers
• Chemicals used in anti-Alzheimer's drug development

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• Chemicals used as neuroprotective agents
• Chemicals used as antioxidants

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A trustworthy factory and manufacturer

Demei Chemical Technology Co., Ltd. is a modern high-tech enterprise integrating R&D, production, and sales. The company's founder, Dr. Arron, born in April 1975, graduated from the School of Mechanical Engineering at Yanshan University and has been engaged in research in the fields of mechanical engineering and chemical synthesis for many years. The company's products focus on the chemical industry, primarily dealing in chemical raw materials and chemical production machinery and equipment. With its strong technical capabilities, advanced production equipment, and strict quality management system, the company has earned the trust of customers worldwide.

1. [Cite:1] HRMS-based profiling of metabolites, metal ions content and in-vitro cholinesterase inhibitory activities of Sonchus wightianus DC plant parts, Electronic Journal of Biotechnology, Volume 79, January 2026, 100702
2. [Cite:2] Targeting PI3K/Akt/mTOR with fisetin mechanistic and therapeutics insights for Parkinson’s disease, Letters in Drug Design & Discovery, 3 February 2026, 100319