Your Location：Home > Products > Pharmaceutical Raw Material > Diltiazem
CasNo： 42399-41-7
MF： C22H26N2O4S
|
Description and Supplier |
Diltiazem is a medication belonging to the class of calcium channel blockers, primarily used to treat hypertension, angina, and certain heart rhythm disorders. DEMEI ELECTRONIC COMMERCE FIRM was established in 2024 and is located in Yiwu, Zhejiang Province. Although it was established not long ago, it has more than ten years of industry experience. The affiliated factory covers an area of 7,000 square meters. In addition, it also has its own excellent reserve of talents. Our high-tech R&D team, workshop production and sales R&D personnel have exceeded 200 people. In recent years, our products have also been exported to the UK, Germany, Australia, the Netherlands, Poland, Russia, Kazakhstan, the Philippines, Malaysia, Singapore and many other regions. , we do business with customers based on the principle of honesty and trustworthiness. We work for customer satisfaction and achieve the greatest recognition from customers within the scope permitted by law. We focus on every detail and strive to provide customers with procurement, research and development, quality control, Grasp the best service in terms of safe transportation, so as to establish long-term cooperative relationships with customers. |
|
Uses |
Diltiazem is an important cardiovascular drug. It is mainly used to treat cardiovascular diseases such as hypertension and angina pectoris. Diltiazem dilates blood vessels, lowers blood pressure, reduces myocardial oxygen consumption, and relieves angina pectoris symptoms by inhibiting the entry of calcium ions into vascular smooth muscle cells. In clinical applications, the therapeutic effect of diltiazem is quite significant, but it may also cause some side effects, such as dizziness, edema, bradycardia, etc. When using diltiazem, the dosage needs to be adjusted according to the patient's specific situation to achieve the best therapeutic effect and reduce the occurrence of side effects. |
|
Definition |
ChEBI: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the m nagement of angina pectoris and hypertension. |
InChI:InChI=1/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
Diltiazem is a drug used as a calcium ch...
Diltiazem (DIL) is a calcium channel blo...
Diltiazem did not reduce the cumulative occurrence of cardiac death, non-fatal reinfarction, or refractory ischaemia during a 6-month follow-up, but did reduce all composite endpoints of non-fatal cardiac events, especially the need for myocardial revascularisation.
Diltiazem hydrochloride, topically appli...
diltiazem hydrochloride
diltiazem
| Conditions | Yield |
|---|---|
|
With sodium carbonate; In water; for 0.333333h;
|
85% |
|
With sodium hydrogencarbonate; In water; ethyl acetate;
|
|
|
With sodium carbonate; In water; pH=7.5;
|
|
|
With sodium hydrogencarbonate; In water; for 0.25h;
|
(2-chloroethyl)dimethylamine hydrochloride
cis-(+)-2-(4'-methoxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazepine-4(5H)-one
butanone
cis-(+)-3-hydroxy-5-[2-(dimethylamino)-ethyl]-2,3-dihydro-2-(4-methoxyphenyl-1,5-benzothiazepine-4(5H)-one
diltiazem
| Conditions | Yield |
|---|---|
|
With acetic anhydride; potassium carbonate; In water;
|
97.2% |
(+/-)-Diltiazem
O-desacetyldiltiazem
acetic anhydride
(2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
O-desacetyldiltiazem
C20H24N2O4S
O-Desmethyldesacetyldiltiazem
N-desmethyldiltiazem
